Stacking 101: How to Combine Supplements for Maximum Benefit

Stacking 101: How to Combine Supplements for Maximum Benefit.

 

An intentional guide to enhancing your microdosing experience with functional support.

If you’ve been exploring microdosing, you may have come across the term “stacking.” It’s a practice that’s gaining popularity for good reason—but it can be confusing if you’re not sure where to start.

This guide will walk you through:
What stacking is
Why it matters
How to do it safely
And which combinations are best for your goals
Let’s start at the root.

What Is Stacking?

In the world of microdosing, stacking refers to combining a psychedelic microdose (typically psilocybin or LSD) with one or more other natural substances—like nootropics, adaptogens, or functional mushrooms—to amplify or balance the effects.
Think of stacking as a way to customize your microdosing experience and align it with your unique needs—whether that’s more energy, focus, calm, or emotional support.
Stacking isn’t about taking more—it’s about taking the right combination.

Why Stack?

Stacking allows you to:

Enhance neuroplasticity and support long-term brain health
Balance stimulating or intense effects with calming or grounding allies
Target specific outcomes like energy, mood, creativity, or focus
Improve the body’s integration of the psychedelic compound
Many of Golden Rule’s products are already intentionally stacked—meaning we’ve combined functional mushrooms, plant allies, and nootropics in precise doses so you don’t have to experiment on your own.

But if you want to explore building your own stack, here’s how to do it.

Popular Stacks by Intention

Stack for Energy + Focus
Best for: Mental performance, productivity, overcoming fatigue

Core Ingredients:
Psilocybin or LSD – Enhances awareness, clarity, and insight
Lion’s Mane – Supports neurogenesis, memory, and cognitive function
Cordyceps – Boosts ATP production, stamina, and energy
Rhodiola Rosea – Reduces fatigue, increases alertness under stress
This stack is perfect for long work sessions, deep creative flow, or high-energy days where you need to stay present without over-relying on caffeine.

Try it:
☑︎ Microdose of psilocybin (100–200mg) or LSD (10–20mcg)
☑︎ 500–1000mg Lion’s Mane
☑︎ 500–1000mg Cordyceps
☑︎ Optional: 100–200mg Rhodiola
Already stacked in: Flow, Super Flow, SOL Gummies

Stack for Mood + Emotional Balance
Best for: Mild depression, anxiety, social ease, emotional regulation

Core Ingredients:
Psilocybin – Opens emotional awareness and supports serotonin balance
Reishi – Calms the nervous system, supports parasympathetic regulation
Maca – Balances hormones and boosts mood
Ashwagandha – Reduces cortisol, helps manage stress
Use this stack when you’re feeling emotionally heavy, flat, or just want to open your heart and reconnect.

Try it:
☑︎ Microdose of psilocybin (100–200mg)
☑︎ 500mg Reishi
☑︎ 500mg Maca
☑︎ Optional: 300mg Ashwagandha
Already stacked in: Happy, Bliss Bites, MiniHappy

Stack for Calm + Grounding
Best for: Overstimulation, anxiety, nervous system regulation, integration

Core Ingredients:
Psilocybin (low dose) – Promotes insight and inner quiet
Reishi – Deeply calming and adaptogenic
L-Theanine – Supports alpha brain waves, relaxation without sedation
Magnesium – Relaxes muscles, eases anxiety and nervous tension
This stack is perfect for rest days, journaling, nervous system recovery, or post-macrodose integration.

Try it:
☑︎ Microdose of psilocybin (50–100mg)
☑︎ 500mg Reishi
☑︎ 100–200mg L-Theanine
☑︎ 200mg Magnesium glycinate
Already stacked in: Zen, Super Zen, Mini Zen

Stack for Creativity + Spiritual Connection
Best for: Art, writing, music, nature immersion, ceremony prep

Core Ingredients:
Psilocybin or LSD – Enhances openness and lateral thinking
Blue Lotus – Adds emotional fluidity, sensuality, and softness
Cacao – A heart-opening stimulant that increases blood flow and serotonin
Damiana – Elevates mood and helps release inhibition

Use this stack to drop into the flow, feel more connected, and let inspiration move through you.

Try it:
☑︎ Microdose of psilocybin (100–200mg)
☑︎ 300mg Blue Lotus extract
☑︎ 1 tsp ceremonial cacao
☑︎ Optional: 250mg Damiana
Already stacked in: Euphoria Truffles, Bliss Bites

Tips for Safe & Intentional Stacking
Start slow. Add one new element at a time so you can observe the effect.
Choose trusted sources. Use high-quality, organic, lab-tested ingredients.
Track your experience. Keep a journal to log what you take and how you feel.
Hydrate + nourish. Psychedelics + herbs work best when your body is well-supported.
Don’t mix with SSRIs or medications without consulting a healthcare provider.

Final Thoughts
Stacking is both a science and an art.
Done intentionally, it can enhance clarity, reduce overwhelm, and help you build a microdosing practice that’s truly aligned with your goals and your body.
But remember—more isn’t always better. Start with presence. Stack with care. Reflect often.

Your path is unique.

Your protocol should be too.

Want to explore pre-stacked blends? Check out Golden Rule’s microdosing lineup, where every capsule and gummy is designed with intention, balance, and your transformation in mind.